CIS 410/510 Bioinformatics

Papers

Introduction
Hunter93.pdf "Molecular Biology for Computer Scientists", by Larry Hunter (Artificial Intelligence and Molecular Biology, MIT Press, 1993).
Pairwise Alignment
Giegerich96.pdf "Pairwise Sequence Alignment", by Robert Giegerich and David Wheeler.
Multiple Alignment
Phillips00.pdf "Multiple Sequence Alignment in Phylogenetic Analysis", by A. Phillips, et al, Molecular Phylogenetics and Evolution 16(3), 2000.
Phylogenetic Trees
treeterm.pdf
treebuilding.pdf
"Trees and Their Terms" and "Introduction to Tree Building", excerpts from Molecular Evolution: A Phylogenetic Approach, by R. Page and E. Holmes, Blackwell Science, 1998.
Martin99.pdf "Mosaic bacterial chromosomes: a challenge en route to a tree of genomes", by William Martin, BioEssays, 1999.
Huelsenbeck02.pdf "Potential Applications and Pitfalls of Bayesian Inference of Phylogeny", by John Huelsenbeck, et al, Syst.Biol. 51(5):673–688, 2002.
Gene Finders
Burge98.pdf "Finding the Genes in Genomic DNA", by Christopher Burge and Samuel Karlin, Current Opinion in Structural Biology, 1998.
Haussler98.pdf "Computational Genefinding", by David Haussler (long version of paper from Trends in Biochemical Sciences, Supplementary Guide to Bioinformatics, 1998)

Web Resources

National Center for Biotechnology Information (NCBI)
http://ncbi.nih.gov Home page.
Science Primer An introduction to the field of bioinformatics and short papers on genomics, phylogenetics, and other topics covered in this course.
ftp://ftp.ncbi.nih.gov/genomes FTP directory of complete genomes.
Bioinformatics Applications
Phylogeny Programs A list of phylogenetic inference applications, maintained by Joe Felsenstein at the University of Washington.
CLUSTAL X Multiple sequence alignment and phylogenetic inference using the neighbor-joining method.
Treeview X Program to display phylogenetic trees; runs on Mac (including OS/X), Unix, Windows).
Programming Languages
Programming Languages Examples Alike Cookbook Code examples from the Perl Cookbook, with some examples shown in other languages.
WWW C++ Information A great set of links put together by Bernd Mohr, former postdoc in Al Malony's lab.
C/C++ Reference Quick reference guide to C++ STL (caveat emptor).
Perl Mongers Unofficial Perl home page; lots of links to on-line info.
PHP Home Page Downloads, manuals, ....
MySQL Home Page Downloads, manuals, ....

Books